Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

Marisa R. Morrow, Battsetseg Batchuluun, Jianhan Wu, +19

Cell Metabolism

HepatologyBiochemistryAtp-citrate LyaseMedicineLiver Physiology +11

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, +17

Nature Communications

Metformin-induced reductions in tumor growth involves modulation of the gut microbiome

Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, +23

Molecular Metabolism

The SGLT2 inhibitor canagliflozin suppresses growth and enhances prostate cancer response to radiotherapy

Amr Ali, Bassem Mekhaeil, Olga‐Demetra Biziotis, +13

Communications Biology

Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non‐small cell lung cancer (NSCLC) through inhibition of HIF‐1α

Olga‐Demetra Biziotis, Evangelia E. Tsakiridis, Amr Ali, +16

Molecular Oncology

Bone cancer-induced pain is associated with glutamate signalling in peripheral sensory neurons

Yong Fang Zhu, Katja Linher‐Melville, Jianhan Wu, +5

Molecular Pain

Pain DisordersTumor InnervationPain MedicineSynaptic TransmissionNeuromodulation Therapies +25

Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice

Eric M. Desjardins, Jianhan Wu, Declan C.T. Lavoie, +13

Cell Reports Medicine

Liver FibrosisImmunologyPathologyHepatic FibrosisPharmacotherapy +21

Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells

William D. Gwynne, Mirza S. Shakeel, Jianhan Wu, +4

Cellular & Molecular Biology Letters

ACLY inhibition promotes tumour immunity and suppresses liver cancer

Jaya Gautam, Jianhan Wu, James Lally, +37

Nature

Kidney Volume and Risk of Incident Kidney Outcomes

Jianhan Wu, Yifan Wang, Caitlyn Vlasschaert, +8

Journal of the American Society of Nephrology