Fred F. Kadlubar

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

Marguerite A. Butler, Nicholas P. Lang, J.F. Young et al. · Pharmacogenetics · 1992 · 418 citations

Medicine, Biochemistry, Oncology +17

Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps.

Nicholas P. Lang, Marguerite A. Butler, Joyce Massengill et al. · PubMed · 1994 · 392 citations

Medicine, Pharmacology, Toxicology +17

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

Robert J. Turesky, Nicholas P. Lang, Mary Ann Butler et al. · Carcinogenesis · 1991 · 342 citations

Pharmacy, Biochemistry, Toxicology +12

Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis.

Fred F. Kadlubar, James A. Miller, Elizabeth C. Miller · PubMed · 1977 · 325 citations

Medicine, Biochemistry, Pharmacology +11