Helen Feilden

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide:  Synthesis and Structure−Activity Relationships

Julia M. Adam, David Jonathan Bennett, A. Bom et al. · Journal of Medicinal Chemistry · 2002 · 233 citations

Medicine, Medicinal Chemistry, Pharmacology +15

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Medicine, Neuroscience, Pharmacology +10

α-Amino Acid Phenolic Ester Derivatives:  Novel Water-Soluble General Anesthetic Agents Which Allosterically Modulate GABA_A Receptors

Alison Anderson, Delia Belelli, David Jonathan Bennett et al. · Journal of Medicinal Chemistry · 2001 · 26 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Structure–activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

Ronald Palin, Lynn Abernethy, Nasrin Ansari et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 24 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10