Ronald Palin

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 451 citations

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide:  Synthesis and Structure−Activity Relationships

Julia M. Adam, David Jonathan Bennett, A. Bom et al. · Journal of Medicinal Chemistry · 2002 · 230 citations

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie · 2002 · 226 citations

Neuromodulation Therapies, Pharmacotherapy, Biomedical Engineering +22

Modified γ-Cyclodextrins and Their Rocuronium Complexes

Kenneth S. Cameron, John K. Clark, Alan Cooper et al. · Organic Letters · 2002 · 35 citations

Bound Rocuronium, Pharmaceutical Science, Bioorganic Chemistry +16

Novel Piperidinium and Pyridinium Agents as Water-Soluble Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Blockade

Ronald Palin, John K. Clark, Phill Cowley et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 34 citations · Full text

Biochemistry, Novel Piperidinium, Medicine +9