Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, +1

Nature Biomedical Engineering

NanoparticlesIntestinal PermeabilityAnionic NanoparticlesEngineeringOral Delivery +5

Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d

Namit Chaudhary, Lisa N. Kasiewicz, Alexandra N. Newby, +9

Nature Biomedical Engineering

Lipid PreparationNanomedicineProteinlipid InteractionBiochemistryAmine Headgroups +7

Profiling of mature-stage human breast milk cells identifies six unique lactocyte subpopulations

John P. Gleeson, Namit Chaudhary, Katherine C. Fein, +3

Science Advances

ImmunologyBreastfeedingHuman LactationUnique Lactocyte SubpopulationsLactation +16

The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology

John P. Gleeson, Katherine C. Fein, Namit Chaudhary, +3

International Journal of Pharmaceutics

ATRP-grown protein-polymer conjugates containing phenylpiperazine selectively enhance transepithelial protein transport

Chad Cummings, Katherine C. Fein, Hironobu Murata, +3

Journal of Controlled Release

Protein SecretionAtrp-grown Protein-polymer ConjugatesBiochemistryNatural SciencesMembrane Transport +5

Intestinal permeation enhancers enable oral delivery of macromolecules up to 70 kDa in size

Katherine C. Fein, John P. Gleeson, Alexandra N. Newby, +1

European Journal of Pharmaceutics and Biopharmaceutics

Gastrointestinal Peptide HormoneBiochemistryMedicinePhysiologyImmunology +11

The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery

Nicholas G. Lamson, Katherine C. Fein, John P. Gleeson, +14

Proceedings of the National Academy of Sciences

NutritionFood FunctionFood Bioactive CompoundBiochemistryMedicine +10

Structure-Function Analysis of Phenylpiperazine Derivatives as Intestinal Permeation Enhancers

Katherine C. Fein, Nicholas G. Lamson, Kathryn A. Whitehead

Pharmaceutical Research

BiochemistryMedicinePhenylpiperazine DerivativesDigestive TractGut Barrier +2

Thrifty, Rapid Intestinal Monolayers (TRIM) Using Caco-2 Epithelial Cells for Oral Drug Delivery Experiments

Nicholas G. Lamson, Rebecca L. Ball, Katherine C. Fein, +1

Pharmaceutical Research

Caco-2 Epithelial CellsCell-based Drug DeliveryPolymer-drug ConjugateMedicineCell Adhesion +6

Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice

Katherine C. Fein, John P. Gleeson, Kyle Cochran, +4

Bioengineering & Translational Medicine