R. Dunsdon

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability

Nicolas Charrier, Brian Clarke, Leanne Cutler et al. · Journal of Medicinal Chemistry · 2008 · 64 citations · Full text

Pharmaceutical Science, Oral Bioavailability, Neurochemical Biomarkers +19

BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

Paul Beswick, Nicolas Charrier, Brian Clarke et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 57 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +10

BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character

Brian Clarke, Emmanuel H. Demont, Colin Dingwall et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 56 citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +12

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics

Nicolas Charrier, Brian Clarke, Leanne Cutler et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 54 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent

Nicolas Charrier, Brian Clarke, Emmanuel H. Demont et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 49 citations · Full text

Medicinal Chemistry, Non-prime Side Substituent, Bioorganic Chemistry +13