Emmanuel H. Demont

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

Omer Gilan, Inmaculada Rioja, Kathy Knezevic et al. · Science · 2020 · 411 citations · Full text

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations

Molecular Pharmacology, Alzheimer's Disease, Biochemistry +13

The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

Romain Gosmini, Van Loc Nguyen, Jérôme Toum et al. · Journal of Medicinal Chemistry · 2014 · 187 citations · Full text

Medicinal Chemistry, Histone Code, Drug Target +12

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain

Robert P. Law, Stephen J. Atkinson, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2018 · 118 citations · Full text

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Emmanuel H. Demont, Paul Bamborough, Chun‐wa Chung et al. · ACS Medicinal Chemistry Letters · 2014 · 88 citations · Full text

Protein Assembly, Molecular Biology, Pharmacotherapy +21