Affinity enhancement of an in vivo matured therapeutic antibody using structure‐based computational design

Louis A. Clark, P. Ann Boriack‐Sjodin, John Eldredge, +12

Protein Science

Crystal StructureEngineeringProtein AssemblyBiomolecular Structure PredictionHydrogen Bond Network +22

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

Mia Rushe, Laura Silvian, Sarah A. Bixler, +9

Structure

Pattern FormationEngineeringInteraction ModelHuman-machine InteractionInteraction Technique +6

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

Lien Nguyen, Fabio Montrasio, Amrutha Pattamatta, +19

Neuron

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisAutoimmune DiseaseImmunologyAntibody Engineering +3

Determinants of the Peptide-induced Conformational Change in the Human Class II Major Histocompatibility Complex Protein HLA-DR1

Aaron K. Sato, Jennifer A. Zarutskie, Mia Rushe, +5

Journal of Biological Chemistry

A Conformational Change in the Human Major Histocompatibility Complex Protein HLA-DR1 Induced by Peptide Binding

Jennifer A. Zarutskie, Aaron K. Sato, Mia Rushe, +4

Biochemistry

Soluble peptide–MHC monomers cause activation of CD8 ⁺ T cells through transfer of the peptide to T cell MHC molecules

Qing Ge, Jennifer D. Stone, Michael T. Thompson, +5

Proceedings of the National Academy of Sciences

The kinetic basis of peptide exchange catalysis by HLA-DM

Jennifer A. Zarutskie, Robert Busch, Zarixia Zavala‐Ruiz, +3

Proceedings of the National Academy of Sciences

Monoclonal Antibodies Specific for the Empty Conformation of HLA-DR1 Reveal Aspects of the Conformational Change Associated with Peptide Binding

Gregory J. Carven, Sriram Chitta, I Hilgert, +8

Journal of Biological Chemistry

HistocompatibilityMonoclonal Antibodies SpecificHla ImmunogeneticsImmunologyMolecular Biology +17

Artemin Crystal Structure Reveals Insights into Heparan Sulfate Binding

Laura Silvian, Ping Jin, Paul Carmillo, +7

Biochemistry

Protein AssemblyGlycobiologyCellular PhysiologyHeparan Sulfate ProteoglycansProtein X-ray Crystallography +17

Structure activity relationships of monocyte chemoattractant proteins in complex with a blocking antibody

Carl E. Reid, Mia Rushe, Matthew Jarpe, +13

Protein Engineering Design and Selection

Protein AssemblyImmunologyImmunologic MechanismAntigen ProcessingImmunotherapeutics +16