Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Austin Gurney, Fumiko Axelrod, Christopher J. Bond, +20

Proceedings of the National Academy of Sciences

ImmunologyCancer BiologyWnt/β-catenin PathwayTumor BiologySignaling Pathway +19

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

Timothy Hoey, Wan-Ching Yen, Fumiko Axelrod, +12

Cell stem cell

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +5

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

Erik S. Zimmerman, Tyler H. Heibeck, Avinash Gill, +16

Bioconjugate Chemistry

Peptide ScienceImmunotherapeuticsResultant AdcsImmunotherapySynthetic Immunology +21

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

Wan-Ching Yen, Marcus Fischer, Fumiko Axelrod, +15

Clinical Cancer Research

Extracellular antigen processing and presentation by immature dendritic cells

Laura Santambrogio, Aaron K. Sato, Gregory J. Carven, +3

Proceedings of the National Academy of Sciences

Abundant empty class II MHC molecules on the surface of immature dendritic cells

Laura Santambrogio, Aaron K. Sato, Falko R. Fischer, +2

Proceedings of the National Academy of Sciences

ImmunologyImmunologic MechanismAntigen ProcessingImmune SystemImmunotherapy +14

A simplified and robust protocol for immunoglobulin expression in <scp><i>E</i></scp><i>scherichia coli</i> cell‐free protein synthesis systems

Cai Qi, Jeffrey Hanson, Alexander Steiner, +7

Biotechnology Progress

Empty and Peptide-Loaded Class II Major Histocompatibility Complex Proteins Produced by Expression inEscherichia coliand Foldingin Vitro

Mia Frayser, Aaron K. Sato, Lihui Xu, +1

Protein Expression and Purification

BiochemistryProtein AssemblyProtein FoldingNatural SciencesPeptide Library +3

Production of bispecific antibodies in “knobs-into-holes” using a cell-free expression system

Yiren Xu, J. Jack Lee, Cuong Tran, +8

mAbs

EngineeringBiomolecular ToolImmunologyAntigen ProcessingImmunotherapy +16

Development of Mammalian Serum Albumin Affinity Purification Media by Peptide Phage Display

Aaron K. Sato, Daniel J. Sexton, Lee A. Morganelli, +13

Biotechnology Progress

Peptide EngineeringPeptide Phage DisplayMolecular BiologyPeptide ScienceProtein Purification +15