The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Mathias Müller, James Briscoe, Carl Laxton, +12

Nature

Complement SystemSignal TransductionSignaling PathwayReceptor Tyrosine KinaseImmunology +7

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.

Mathias Müller, Carl Laxton, James Briscoe, +5

The EMBO Journal

Central RoleDevelopmental BiologySignal TransductionSignaling PathwayProtein Expression +8

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam, +17

Journal of Biological Chemistry

Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene

Andrew M. Ackrill, Graham R. Foster, Carl Laxton, +3

Nucleic Acids Research

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

David B. Smith, Joseph A. Martin, Klaus Klumpp, +21

Bioorganic & Medicinal Chemistry Letters

Viral ReplicationBiochemistryNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +9

Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response

Morris Paterson, Carl Laxton, Howard C. Thomas, +2

Gastroenterology

Interferon Antiviral ActivityHepatologyViral HepatitisImmunologyAntiviral Drug Development +7

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

Mark Fidock, B E Souberbielle, Carl Laxton, +15

Clinical Pharmacology & Therapeutics

Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection

A. K. Thomas, Carl Laxton, Joanne Rodman, +3

Antimicrobial Agents and Chemotherapy

Innate Immune SystemImmunologyImmunologic MechanismInnate ImmunityAntiviral Drug +18

Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site

Carl Laxton, Kevin Brady, Sterghios Moschos, +7

Antimicrobial Agents and Chemotherapy

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection

Thien-Duc Tran, David C. Pryde, Peter Jones, +21

Bioorganic & Medicinal Chemistry Letters

HepatologyViral HepatitisImmunologyPharmacologyHepatitis +7