Carl Laxton

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Mathias Müller, James Briscoe, Carl Laxton et al. · Nature · 1993 · 771 citations

Life Sciences, Immunology, Molecular Biology +12

Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

Mathias Müller, Carl Laxton, James Briscoe et al. · The EMBO Journal · 1993 · 415 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam et al. · Journal of Biological Chemistry · 2005 · 215 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +15

Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene

Andrew M. Ackrill, Graham R. Foster, Carl Laxton et al. · Nucleic Acids Research · 1991 · 117 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

David B. Smith, Joseph A. Martin, Klaus Klumpp et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 97 citations

Pharmacy, Biochemistry, Medicinal Chemistry +16