MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth, +54

Nature

Tumor BiologyDntp PoolMth1 InhibitionOncologyMedicine +6

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Torkild Visnes, Armando Cázares‐Körner, Wenjing Hao, +37

Science

Validation and development of MTH1 inhibitors for treatment of cancer

Ulrika Warpman Berglund, Kumar Sanjiv, Helge Gad, +44

Annals of Oncology

OncologyMedicinePathologyAnti-cancer AgentMetronomic Chemotherapy +5

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

Nikolas Herold, Sean G. Rudd, Linda Ljungblad, +31

Nature Medicine

Hematological MalignancyTumor BiologyCytarabine TherapyNovel TherapyMedicine +11

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Nina Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, +18

Nature Communications

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Robert Gustafsson, Ann‐Sofie Jemth, Nina Gustafsson, +12

Cancer Research

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, +65

Nature Cancer

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Maurice Michel, Carlos Benitéz‐Buelga, Patricia A. Calvo, +54

Science

Dna DamageMolecular BiologySmall-molecule ActivationRedox BiologyOxidative Stress +17

Ribonucleotide reductase inhibitors suppress <scp>SAMHD</scp> 1 ara‐ <scp>CTP</scp> ase activity enhancing cytarabine efficacy

Sean G. Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, +32

EMBO Molecular Medicine

Mixed-phenotype Acute LeukemiaImmunologyPharmacotherapyTumor BiologyMyeloid Neoplasia +16

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Torkild Visnes, Carlos Benitéz‐Buelga, Armando Cázares‐Körner, +43

Nucleic Acids Research