Denis R. Alexander

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

Karen Byth, L A Conroy, Sarah Howlett et al. · The Journal of Experimental Medicine · 1996 · 367 citations · Full text

Lymphocyte Development, T-regulatory Cell, Immunology +21

Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

James I. Elliott, Annmarie Surprenant, Federica M. Marelli‐Berg et al. · Nature Cell Biology · 2005 · 221 citations · Full text

Signal Transduction, Membrane Phosphatidylserine Distribution, Cell Trafficking +12

The Differential Regulation of Lck Kinase Phosphorylation Sites by CD45 Is Critical for T Cell Receptor Signaling Responses

Louise McNeill, Robert J. Salmond, Joanne C. Cooper et al. · Immunity · 2007 · 187 citations · Full text

Systems Biology, Signal Transduction, Signaling Pathway +11

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

Masahiro Shiroo, Lindsey K. Goff, Mark Biffen et al. · The EMBO Journal · 1992 · 175 citations · Full text

Calcium Influx, Signal Transduction, Molecular Physiology +12

CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases

Christine Guntermann, Denis R. Alexander · The Journal of Immunology · 2002 · 126 citations · Full text