Acute Effects of Atypical Antipsychotics on Whole-Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects

Karen L. Houseknecht, Alan S. Robertson, William J. Zavadoski, +3

Neuropsychopharmacology

ObesityMetabolic SyndromeWhole-body Insulin ResistancePsychiatryAtypical Antipsychotics +11

Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield, +41

Journal of Medicinal Chemistry

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

Sumeet A. Khetarpal, Xuemei Zeng, John S. Millar, +19

Nature Medicine

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Robert L. Dow, Jiancheng Li, Michael P. Pence, +13

ACS Medicinal Chemistry Letters

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryInsulin SignalingMetabolic Syndrome +14

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Jianxin Yang, Margit MacDougall, Michael T. McDowell, +8

BMC Genomics

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle

Atul S. Deshmukh, Yun Chau Long, Thaís de Castro Barbosa, +7

Diabetologia

The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic <i>ob/ob</i> Mouse

Rashmi Kumari, Lisa B. Willing, Shyama D. Patel, +5

Journal of Cerebral Blood Flow & Metabolism

Lipid PeroxidationInsulin SignalingDb/db MiceOxidative StressNeuroinflammation +20

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

Michael P. DeNinno, Melissa P. Andrews, Andrew Bell, +10

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ScienceBiochemistryMedicinePharmacological AgentPharmacotherapy +6

The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus

Angel Guzmán-Pérez, Jeffrey A. Pfefferkorn, Esther C.Y. Lee, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDiabetes ManagementMedicineDrug DiscoveryDiabetes +9

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans

Benjamin S. Maciejewski, Jennifer L. LaPerle, Danny Z. Chen, +11

American Journal of Physiology-Gastrointestinal and Liver Physiology

Dietary Lipid AbsorptionPharmacological InhibitionDgat1 InhibitionGastrointestinal Peptide HormoneObesity +15