γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor

Hua Zhang, Jennifer Kovacs-Nolan, Tomohiro Kodera, +2

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

InflammationAllergyMucosal ImmunologyImmune RegulationImmunology +8

Identification of an Angiotensin I‐converting Enzyme Inhibitory Peptides from Protein Hydrolysates by a Soybean Protease and the Antihypertensive Effects of Hydrolysates in 4 Spontaneously Hypertensive Model Rats

Tomohiro Kodera, Noriki Nio

Journal of Food Science

A novel l-isoleucine hydroxylating enzyme, l-isoleucine dioxygenase from Bacillus thuringiensis, produces (2S,3R,4S)-4-hydroxyisoleucine

Tomohiro Kodera, Sergey V. Smirnov, Natalya N. Samsonova, +6

Biochemical and Biophysical Research Communications

BiosynthesisEngineeringBiotransformationBiochemistryNatural Sciences +9

Metabolic engineering of Escherichia coli to produce (2S, 3R, 4S)-4-hydroxyisoleucine

Sergey V. Smirnov, Tomohiro Kodera, Natalya N. Samsonova, +7

Applied Microbiology and Biotechnology

BiosynthesisEngineeringBiotransformationBiochemistryNatural Sciences +9

Characterization of Bacillus thuringiensis <scp>l</scp> -Isoleucine Dioxygenase for Production of Useful Amino Acids

Makoto Hibi, Takashi Kawashima, Tomohiro Kodera, +6

Applied and Environmental Microbiology

EngineeringMicrobial PhysiologyUseful Amino AcidsEnzymatic ModificationBiosynthesis +14

A novel l-isoleucine metabolism in Bacillus thuringiensis generating (2S,3R,4S)-4-hydroxyisoleucine, a potential insulinotropic and anti-obesity amino acid

Jun Ogawa, Tomohiro Kodera, Sergey V. Smirnov, +8

Applied Microbiology and Biotechnology

BiosynthesisEnergy MetabolismEngineeringBiochemistryBacillus Thuringiensis Generating +10

l-Leucine 5-hydroxylase of Nostoc punctiforme is a novel type of Fe(II)/α-ketoglutarate-dependent dioxygenase that is useful as a biocatalyst

Makoto Hibi, Takashi Kawashima, Pavel Sokolov, +6

Applied Microbiology and Biotechnology

BiosynthesisNovel TypeBiochemistryCellular EnzymologyL-leucine 5-Hydroxylase +7

Multi‐Enzymatic Synthesis of Optically Pure β‐Hydroxy α‐Amino Acids

Makoto Hibi, Takuya Kasahara, Takashi Kawashima, +8

Advanced Synthesis & Catalysis

New Production SystemBiosynthesisMulti‐enzymatic SynthesisEngineeringBiochemistry +9

A novel strategy for enzymatic synthesis of 4-hydroxyisoleucine: identification of an enzyme possessing HMKP (4-hydroxy-3-methyl-2-keto-pentanoate) aldolase activity

Sergey V. Smirnov, Natalya N. Samsonova, Anna E. Novikova, +6

FEMS Microbiology Letters

EngineeringAldo-keto ReductaseEnzymatic SynthesisAldolase ActivityEnzymatic Modification +14

Synthesis of 4-Hydroxyisoleucine by the Aldolase–Transaminase Coupling Reaction and Basic Characterization of the Aldolase from<i>Arthrobacter simplex</i>AKU 626

Jun Ogawa, Hiroyuki Yamanaka, Jun’ichi Mano, +8

Bioscience Biotechnology and Biochemistry