David J. Spalding

Improving the in Vitro Prediction of in Vivo Central Nervous System Penetration: Integrating Permeability, P-glycoprotein Efflux, and Free Fractions in Blood and Brain

Scott Summerfield, Alexander J. Stevens, Leanne Cutler et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 176 citations

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: Relationship to the presence of immunoidentified cytochrome P-450IID1

Örjan Mortimer, Kerstin Persson Waye, Margarita G. Ladona et al. · Clinical Pharmacology & Therapeutics · 1990 · 81 citations

Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2

Stuart Cockerill, Colin Stubberfield, Jeremy N. Stables et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 79 citations · Full text

Medicinal Chemistry, Indazolylamino Quinazolines, Medicine +10

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Gerard M.P. Giblin, Rino A. Bit, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · Full text

Inflammation, Medicinal Chemistry, Anti-inflammatory +13

Human fetal and adult liver metabolism of ethylmorphine

Margarita G. Ladona, David J. Spalding, Lena Ekman et al. · Biochemical Pharmacology · 1989 · 44 citations

Hepatology, Medicine, Liver Physiology +11