Maria Kliachyna

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Guillaume Mercey, Tristan Verdelet, Julien Renou et al. · Accounts of Chemical Research · 2012 · 401 citations

Life Sciences, Pharmacology, Toxicology +17

1‐Substituted 2‐Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

Alexander A. Kirichok, Iryna Shton, Maria Kliachyna et al. · Angewandte Chemie International Edition · 2017 · 87 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum et al. · European Journal of Medicinal Chemistry · 2014 · 78 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +15

Design, synthesis and evaluation of new α-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase

Géraldine Saint-André, Maria Kliachyna, Sanjeevarao Kodepelly et al. · Tetrahedron · 2011 · 73 citations

Life Sciences, Biochemistry, Pharmacology +11

Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents

Julien Renou, Guillaume Mercey, Tristan Verdelet et al. · Chemico-Biological Interactions · 2012 · 57 citations

Life Sciences, Biochemistry, Pharmacology +14