Gianluca Santoni

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum et al. · European Journal of Medicinal Chemistry · 2014 · 78 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +15

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

Diana C. F. Monteiro, David von Stetten, Claudia Stohrer et al. · IUCrJ · 2020 · 60 citations · Full text

Engineering, Bioengineering, Biophysics +17

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Gianluca Santoni, Julien de Sousa, E. De la Mora et al. · Journal of Medicinal Chemistry · 2018 · 58 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Julien Lalut, Gianluca Santoni, Delphine Karila et al. · European Journal of Medicinal Chemistry · 2018 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Inhibition Pathways of the Potent Organophosphate CBDP with Cholinesterases Revealed by X-ray Crystallographic Snapshots and Mass Spectrometry

E. Carletti, Jacques‐Philippe Colletier, Lawrence M. Schopfer et al. · Chemical Research in Toxicology · 2013 · 48 citations

Life Sciences, Biochemistry, Pharmacology +17