Gianluca Santoni

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum et al. · European Journal of Medicinal Chemistry · 2014 · 77 citations · Full text

Medicinal Chemistry, -Amidoxime Hybrids, Bioorganic Chemistry +11

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Gianluca Santoni, Julien de Sousa, E. De la Mora et al. · Journal of Medicinal Chemistry · 2018 · 56 citations · Full text

Combinatorial Chemistry, Ache Activity, Bioorganic Chemistry +16

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

Diana C. F. Monteiro, David von Stetten, Claudia Stohrer et al. · IUCrJ · 2020 · 56 citations · Full text

Engineering, Microscopy, Analytical Microsystems +16

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Julien Lalut, Gianluca Santoni, Delphine Karila et al. · European Journal of Medicinal Chemistry · 2018 · 48 citations · Full text

Lead Compounds, Alzheimer's Disease, Biochemistry +10

Inhibition Pathways of the Potent Organophosphate CBDP with Cholinesterases Revealed by X-ray Crystallographic Snapshots and Mass Spectrometry

E. Carletti, Jacques‐Philippe Colletier, Lawrence M. Schopfer et al. · Chemical Research in Toxicology · 2013 · 45 citations