Kaitlyn M. Cahuzac

Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders

Xufen Yu, Jia Xu, Ling Xie et al. · Journal of Medicinal Chemistry · 2021 · 51 citations · Full text

AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Kaitlyn M. Cahuzac, Abigail Lubin, Kaitlyn Bosch et al. · Cell Reports · 2023 · 43 citations · Full text

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies

Xufen Yu, Jia Xu, Yudao Shen et al. · Journal of Medicinal Chemistry · 2022 · 37 citations · Full text

Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells

Xufen Yu, Jia Xu, Kaitlyn M. Cahuzac et al. · Journal of Medicinal Chemistry · 2022 · 32 citations · Full text