Concepedia
Author
Kaitlyn M. Cahuzac
Also Known As
15
Publications
163
Citations
4
H-Index
0
Concepts
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Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders
Xufen Yu, Jia Xu, Ling Xie, +7
Journal of Medicinal Chemistry
2021
51
AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
Kaitlyn M. Cahuzac, Abigail Lubin, Kaitlyn Bosch, +6
Cell Reports
2023
43
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure–Activity Relationship Studies
Xufen Yu, Jia Xu, Yudao Shen, +6
2022
37
Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells
Xufen Yu, Jia Xu, Kaitlyn M. Cahuzac, +6
32
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