Yulia Volovik Frenkel

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

Kalyan Das, Joseph D. Bauman, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 2008 · 335 citations · Full text

Viral Replication, Engineering, Molecular Biology +21

Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability

Yulia Volovik Frenkel, Arthur D. Clark, Kalyan Das et al. · Journal of Medicinal Chemistry · 2005 · 128 citations

Structural basis of HIV-1 resistance to AZT by excision

Xiongying Tu, Kalyan Das, Qianwei Han et al. · Nature Structural & Molecular Biology · 2010 · 119 citations · Full text

Hiv-1 Resistance, Human Retrovirus, Immunology +7

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

Joseph D. Bauman, Disha Patel, Chhaya Dharia et al. · Journal of Medicinal Chemistry · 2013 · 90 citations · Full text

Structural Bioinformatics, Molecular Biology, Nucleic Acid Amplification Test +17

Molecular Dynamics Study of Non-nucleoside Reverse Transcriptase Inhibitor 4-[[4-[[4-[(<i>E</i>)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/Rilpivirine) Aggregates: Correlation between Amphiphilic Properties of the Drug and Oral Bioavailability

Yulia Volovik Frenkel, Emilio Gallicchio, Kalyan Das et al. · Journal of Medicinal Chemistry · 2009 · 17 citations · Full text