Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

Katharina Essig, Desheng Hu, Joao C. Guimaraes, +19

Immunity

Pi3k-mtor Signaling PathwaySignal TransductionSignaling PathwayReceptor Tyrosine KinaseT-regulatory Cell +8

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon J. Tavernier, Vicki Athanasopoulos, Patrick Verloo, +25

Nature Communications

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, +14

Nature Communications

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses

Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, +17

Nature Immunology

Roquin-1 InteractionAutoimmune DiseaseSignaling PathwayMedicineImmunology +10

Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Kai P. Hoefig, Alexander Reim, Christian Gallus, +16

Nature Communications

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

Matthias von Gamm, Annalisa Schaub, Alisha Jones, +23

The Journal of Experimental Medicine

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

Nina Rehage, Elena Davydova, Christine Conrad, +17

Nature Communications

A translational silencing function of MCPIP1/Regnase-1 specified by the target site context

Gesine Behrens, Reinhard Winzen, Nina Rehage, +7

Nucleic Acids Research

ImmunologySignal RecognitionMolecular BiologyMolecular ResearchSl Structures +16

Interleukin-17 (IL-17) and IL-1 Activate Translation of Overlapping Sets of mRNAs, Including That of the Negative Regulator of Inflammation, MCPIP1

Sonam Dhamija, Reinhard Winzen, Anneke Doerrie, +7

Journal of Biological Chemistry

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity

Henrik Schmidt, Timsse Raj, Thomas J. O’Neill, +18

Proceedings of the National Academy of Sciences