Pau Castel

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Dejan Juric, Pau Castel, Malachi Griffith et al. · Nature · 2014 · 561 citations · Full text

Signal Transduction, Clinical Resistance, Signaling Pathway +8

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

Ana Bosch, Zhiqiang Li, Anna Bergamaschi et al. · Science Translational Medicine · 2015 · 418 citations · Full text

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Eneda Toska, Hatice U. Osmanbeyoglu, Pau Castel et al. · Science · 2017 · 260 citations · Full text

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Fara Brasó‐Maristany, Simone Filosto, Steven Catchpole et al. · Nature Medicine · 2016 · 238 citations · Full text

Breast Oncology, Oncology, Medicine +12

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

Pau Castel, Haley Ellis, Ružica Bago et al. · Cancer Cell · 2016 · 222 citations · Full text

Molecular Physiology, Signal Transduction, Pi3kα Inhibition +9