Bactericidal Action of Daptomycin against Stationary-Phase and Nondividing <i>Staphylococcus aureus</i> Cells

Carmela Mascio, Jeff Alder, Jared Silverman

Antimicrobial Agents and Chemotherapy

Antimicrobial ChemotherapyDrug ResistanceInfection ControlAntibacterial MechanismsAntimicrobial Resistance +15

Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

Kien T. Nguyen, Xiaowei He, Dylan C. Alexander, +9

Antimicrobial Agents and Chemotherapy

Improved PropertiesPulmonary SurfactantEngineeringAntibiotic AdjuvantBovine Surfactant +15

<i>In Vitro</i> and <i>In Vivo</i> Characterization of CB-183,315, a Novel Lipopeptide Antibiotic for Treatment of Clostridium difficile

Carmela Mascio, Lawrence I. Mortin, Karen Howland, +7

Antimicrobial Agents and Chemotherapy

Microbial PathogensSpontaneous Resistance IncidenceAntimicrobial ChemotherapyAntibiotic ResistanceBacterial Pathogens +22

Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficile

Mohammed Zahidul Alam, Xiaoqian Wu, Carmela Mascio, +2

Antimicrobial Agents and Chemotherapy

Antibacterial AgentsBactericidal PropertiesAntimicrobial ChemotherapyNongrowing Clostridium DifficileInfection Control +17

Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions

Dylan C. Alexander, Jessica L. Rock, Jian-Qiao Gu, +4

The Journal of Antibiotics

Lptl Gene FunctionsBiosynthesisAmino AcidsBiochemistryMicrobial Genetics +9

Surotomycin Demonstrates Low <i>In Vitro</i> Frequency of Resistance and Rapid Bactericidal Activity in Clostridium difficile, Enterococcus faecalis, and Enterococcus faecium

Carmela Mascio, Laurent Chesnel, Grace M. Thorne, +1

Antimicrobial Agents and Chemotherapy

Enterococcus FaeciumAntimicrobial ChemotherapyAntibiotic ResistanceBacterial PathogensDrug Resistance +22

Structure–Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of <i>Clostridium difficile</i>-Associated Diarrhea

Ning Yin, Jing Li, Yong He, +13

Journal of Medicinal Chemistry

Antimicrobial Drug DiscoveryDerivativesPharmaceutical ChemistryBiochemistryAntibiotics +13

Effects of Surotomycin on Clostridium difficile Viability and Toxin Production <i>In Vitro</i>

Laurent Bouillaut, Shonna M. McBride, Joseph A. Sorg, +6

Antimicrobial Agents and Chemotherapy

Antimicrobial ChemotherapyBacterial PathogensDrug ResistanceToxicologyInfection Control +19

Mutations Associated with Reduced Surotomycin Susceptibility in Clostridium difficile and Enterococcus Species

Hannah M. Adams, Xiang Li, Carmela Mascio, +2

Antimicrobial Agents and Chemotherapy

Reduced Surotomycin SusceptibilityCdi RelapseAntimicrobial SusceptibilityHealth SciencesAntibiotics +13

Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids

Yong He, Jing Li, Nin Yin, +10

Bioorganic & Medicinal Chemistry Letters

Tryptophan ReplacementDaptomycin AnalogsBiochemistryMedicineAntibiotic Adjuvant +7