William J. Thompson

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

William J. Thompson, Gary A. Piazza, Han Li et al. · PubMed · 2000 · 305 citations

Apoptosis, Cell Death, Tumor Biology +17

Direct activation of PDE5 by cGMP

Florian Müllershausen, Andreas Friebe, Robert Feil et al. · The Journal of Cell Biology · 2003 · 156 citations · Full text

Signal Recognition, Molecular Biology, Cellular Physiology +21

Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

Jae Won Soh, Y. K. Mao, Min‐Gul Kim et al. · PubMed · 2000 · 134 citations

Chemoprevention Strategy, Sulindac Derivatives, Apoptosis +20

Rapid nitric oxide–induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

Florian Müllershausen, Michael Russwurm, William J. Thompson et al. · The Journal of Cell Biology · 2001 · 126 citations · Full text

Cellular Physiology, Inflammation, Molecular Pharmacology +19

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.

Gary A. Piazza, William J. Thompson, Rifat Pamukcu et al. · PubMed · 2001 · 124 citations

Urological Research, Urology, Cyclic Amp Levels +15