Rifat Pamukcu

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

Gary A. Piazza, Alanna L. Kulchak Rahm, Mary F. Krutzsch et al. · PubMed · 1995 · 434 citations

Tumor Biology, Medicinal Chemistry, Oncology +14

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

Gary A. Piazza, David S. Alberts, Lee J. Hixson et al. · PubMed · 1997 · 361 citations

Chemoprevention Strategy, Prostaglandin Levels, Gastrointestinal Pharmacology +16

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

Gary A. Piazza, A K Rahm, T S Finn et al. · PubMed · 1997 · 354 citations

Chemoprevention Strategy, Apoptosis, Cell Death +17

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

William J. Thompson, Gary A. Piazza, Han Li et al. · PubMed · 2000 · 305 citations

Apoptosis, Cell Death, Tumor Biology +17

Rapid development of colitis in NSAID-treated IL-10–deficient mice

Daniel Berg, Juan Zhang, Joel V. Weinstock et al. · Gastroenterology · 2002 · 275 citations

Inflammation, Chronic Inflammatory Diseases, Mucosal Immunology +8