Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Nobuhiko Kayagaki, Michael T. Wong, Irma B. Stowe, +10

Science

Innate Immune SystemImmunologyEscherichia ColiInnate ImmunityImmunotherapy +15

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

Xiaoting Wang, Naruhisa Ota, Paolo Manzanillo, +11

Nature

InflammationMetabolic SyndromeCytokineDiabetesImmunology +7

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

Amanda Littlewood‐Evans, Sophie Sarret, Verena Apfel, +12

The Journal of Experimental Medicine

ImmunologyImmune RegulationInnate ImmunityImmune SystemExtracellular Succinate +21

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Yi Zhou, Mingjian Fei, Gu Zhang, +25

Immunity

InflammationPhagocytic Receptor MertkCytokineMedicineImmunology +8

Rapid development of colitis in NSAID-treated IL-10–deficient mice

Daniel Berg, Juan Zhang, Joel V. Weinstock, +6

Gastroenterology

InflammationChronic Inflammatory DiseasesMucosal ImmunologyImmunodeficienciesImmune Regulation +6

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Ingrid E. Wertz, Kim Newton, Dhaya Seshasayee, +31

Nature

InflammationAnti-inflammatoryAutoimmune DiseaseMedicineImmunology +5

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

Dhaya Seshasayee, Wyne P. Lee, Meijuan Zhou, +18

Journal of Clinical Investigation

AsthmaInflammatory Lung DiseaseVivo BlockadeAllergy MedicineImmune Regulation +15

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, +19

Nature

InflammationApoptosisImmunologyOtulin LimitsCell Death +3

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

Joschka Willemsen, Marie‐Therese Neuhoff, Thomas Hoyler, +10

Cell Reports

ImmunologyPathologyCgas/sting-dependent Interferon ResponsesInflammatory ArthritisInflammation +16

Phosphorylation of Syk Activation Loop Tyrosines Is Essential for Syk Function

Juan Zhang, Melvin L. Billingsley, Randall L. Kincaid, +1

Journal of Biological Chemistry