Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

Xiaoting Wang, Naruhisa Ota, Paolo Manzanillo, +11

Nature

InflammationMetabolic SyndromeCytokineDiabetesImmunology +7

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Rajkumar Noubade, Kit Hong Wong, Naruhisa Ota, +14

Nature

InflammationHost ResponseAllergyAutoimmune DiseaseHost Defence +8

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells

Sascha Rutz, Rajkumar Noubade, Céline Eidenschenk, +7

Nature Immunology

InflammationIl-22 ProductionTranscriptional RegulationCytokineMedicine +9

Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection

Melba Muñoz, Céline Eidenschenk, Naruhisa Ota, +14

Immunity

InflammationCytokineMucosal ImmunologyImmunologyGastroenterology +5

TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers

Xueying Yu, Rajita Pappu, Vladimir Ramirez-Carrozzi, +7

Mucosal Immunology

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Naruhisa Ota, Kit Hong Wong, Patricia Valdez, +4

Nature Immunology

InflammationCytokinePathogenesisImmunologyMicrobiology +8

IL-17RC Is Required for IL-17A– and IL-17F–Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Yan Hu, Naruhisa Ota, Ivan Peng, +4

The Journal of Immunology

ImmunodeficienciesImmunologyImmune RegulationIl-17a Signal TransductionImmunologic Mechanism +19

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

Jennifer H. Cox, Noelyn M. Kljavin, Naruhisa Ota, +5

Mucosal Immunology

InflammationCytokineInflammatory DiseaseMucosal ImmunologyAdaptive Cells +9

N-domain–dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation

Naruhisa Ota, Tom J. Brett, Theresa L. Murphy, +2

Nature Immunology

CytokineSignal TransductionImmune Cell DevelopmentImmunologyCytokine-driven Activation +4

Structure of the core human NADPH oxidase NOX2

Sigrid Noreng, Naruhisa Ota, Yonglian Sun, +13

Nature Communications