c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn, Evan W. Weber, Elena Sotillo, +16

Nature

PhysiologyAutoimmunityTolerance InductionImmunotherapyMedicine +4

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber, Kevin R. Parker, Elena Sotillo, +23

Science

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication

Johanna Theruvath, Marie Ménard, Benjamin Smith, +39

Nature Medicine

Tumor EradicationImmunologyImmune Checkpoint InhibitorTumor TargetingImmunotherapy +1

Pharmacologic control of CAR-T cell function using dasatinib

Evan W. Weber, Rachel C. Lynn, Elena Sotillo, +3

Blood Advances

Cell TherapySafety SwitchCar-t Cell FunctionImmunologyImmune Checkpoint Inhibitor +10

FOXO1 is a master regulator of memory programming in CAR T cells

Alexander Doan, Katherine P. Mueller, Andy Y. Chen, +31

Nature

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Amanda Heard, Jack H. Landmann, Ava R. Hansen, +16

Nature Communications

Antigen GlycosylationChimeric Antigen ReceptorCd19 GenesCancer ImmunosurveillanceAutoimmune Disease +13

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

Mehmet Emrah Selli, Jack H. Landmann, Marina Terekhova, +18

Blood

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

Mehmet Emrah Selli, Jack H. Landmann, Marina Terekhova, +18

Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

Evan W. Weber, Rachel C. Lynn, Kevin R. Parker, +15

Transcription Factors Tcf1Epigenetic ChangeImmunologyImmunotherapeuticsCar-t Cell +23

Abstract 2563: Macrophage Toll-like receptor-chimeric antigen receptors (MOTO-CARs) as a novel adoptive cell therapy for the treatment of solid malignancies

Edwin J. Velazquez, John Lattin, Taylor D. Brindley, +11

Cancer Research

ImmunologyImmunoeditingImmune Cell TherapyT CellsImmunotherapy +14