Publication | Open Access
Pharmacologic control of CAR-T cell function using dasatinib
222
Citations
23
References
2019
Year
Cell TherapySafety SwitchCar-t Cell FunctionImmunologyImmune Checkpoint InhibitorCar-mediated ToxicityTolerance InductionCell BiologyCellular Immune ResponseKey Points DasatinibImmunotherapyMedicineCell TransplantationCell SignalingNovel Therapy
Key Points Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.
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