Yuichiro Higashimoto

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Mark Pearson, Roberta Carbone, Carla Sebastiani et al. · Nature · 2000 · 826 citations

P53 Acetylation, Oncogenic Ras, Cell Regulation +9

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

Gabriella D’Orazi, Barbara Cecchinelli, Tiziana Bruno et al. · Nature Cell Biology · 2001 · 673 citations

Ser 46, Signaling Pathway, Apoptosis +7

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

Akihiro Ito, Yoshiharu Kawaguchi, Chun-Hsiang Lai et al. · The EMBO Journal · 2002 · 563 citations · Full text

Mdm2–hdac1-mediated Deacetylation, Medicine, Molecular Biology +7

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Dmitry V. Bulavin, Yuichiro Higashimoto, Ian J. Popoff et al. · Nature · 2001 · 527 citations

Tumor Biology, Ultraviolet Radiation, Cell Regulation +14

A Rational Strategy to Design Multiepitope Immunogens Based on Multiple Th Lymphocyte Epitopes

Brian Livingston, Claire Crimi, Mark J. Newman et al. · The Journal of Immunology · 2002 · 357 citations · Full text