Barbara Birk

Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Ruth Werth et al. · Journal of Medicinal Chemistry · 2008 · 107 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

In Vivo Active Aldosterone Synthase Inhibitors with Improved Selectivity: Lead Optimization Providing a Series of Pyridine Substituted 3,4-Dihydro-1<i>H</i>-quinolin-2-one Derivatives

Simon Lucas, Ralf Heim, Christina Ries et al. · Journal of Medicinal Chemistry · 2008 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Matthias Negri et al. · Journal of Medicinal Chemistry · 2009 · 76 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

Eric Fabian, Caroline Gomes, Barbara Birk et al. · Archives of Toxicology · 2018 · 75 citations · Full text

Pharmacy, Pharmacology, Toxicology +16

In Silico Models to Predict the Perturbation of Molecular Initiating Events Related to Thyroid Hormone Homeostasis

Marina García de Lomana, Andreas Georg Weber, Barbara Birk et al. · Chemical Research in Toxicology · 2020 · 62 citations · Full text

Engineering, Biochemistry, Endocrinology +16