James T. Topham

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Michelle Chan‐Seng‐Yue, Jaeseung Kim, Gavin W. Wilson et al. · Nature Genetics · 2020 · 644 citations · Full text

Systems Biology, Transcription Phenotypes, Pancreatic Cancer +7

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

Paul C. McDonald, Shawn C. Chafe, Wells S. Brown et al. · Gastroenterology · 2019 · 225 citations · Full text

<i>NRG1</i> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <i>KRAS</i> Wild-Type Pancreatic Ductal Adenocarcinoma

Martin Jones, Laura Williamson, James T. Topham et al. · Clinical Cancer Research · 2019 · 157 citations

The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma

Daniel J. Renouf, Jonathan M. Loree, Jennifer J. Knox et al. · Nature Communications · 2022 · 119 citations · Full text

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

Hye-Jung E. Chun, Pascal D. Johann, Katy Milne et al. · Cell Reports · 2019 · 115 citations · Full text