Thomas G. Hayhow

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

P. G. Humphreys, Paul Bamborough, Chun‐wa Chung et al. · Journal of Medicinal Chemistry · 2016 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy

Adrian Hall, Andy Billinton, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 76 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives

Susan M. Westaway, Alex Preston, Michael D. Barker et al. · Journal of Medicinal Chemistry · 2016 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor

Jonathan T. Seal, Stephen J. Atkinson, Helen Aylott et al. · Journal of Medicinal Chemistry · 2020 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

Susan M. Westaway, Alex Preston, Michael D. Barker et al. · Journal of Medicinal Chemistry · 2016 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15