Mark R. Spyvee - Concepedia

Author

Mark R. Spyvee

Eisai (United States)

Also Known As

M Spyvee, M. R. SPYVEE, M. SPYVEE, M. Spyvee, Mark R Spyvee, Mark R. Spyvee, Mark Spyvee, Spyvee, M.

Publications

551

Citations

H-Index

Concepts

All Affiliations

Eisai (United States)Eisai (Japan)University of Oxford The University of Texas at Austin

About

Mark R. Spyvee is an author at Eisai (United States) specializing in natural sciences, biochemistry, and organic chemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	8	8	219
2	Biochemistry	8	8	219
3	Medicine	5	5	148
4	Engineering	2	2	38
5	Biomolecular Engineering	2	2	47

Mark R. Spyvee

Publications

540

Citations

H-Index

Page 1

	Year	Citations
Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo Marc S. Lamphier, Wanjun Zheng, Eicke Latz, Molecular Pharmacology	2013	139
A novel antagonist of the prostaglandin E<sub>2</sub> EP<sub>4</sub> receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models Q Chen, Kazuyo Muramoto, Nagashima Masaaki, British Journal of Pharmacology	2010	94
Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin Galina Kuznetsov, Karen TenDyke, Murray J. Towle, Molecular Cancer Therapeutics Purified TubulinApoptosisCell DeathCytoskeletonChemical Biology	2009	69
Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead Hong Du, Tomohiro Matsushima, Mark R. Spyvee, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryAnti-inflammatoryBiochemistryNatural SciencesMedicine	2009	28
Concise syntheses of acromelic acid A and allo-acromelic acid A Jack E. Baldwin, Andrew M. Fryer, Gareth J. Pritchard, Tetrahedron Letters Concise SynthesesBioorganic ChemistryBiochemistryNatural SciencesBiomolecular Engineering	1998	26
Biomimetic syntheses of stizolobic acid and 3-(6-carboxy-2-oxo-4-pyridyl)alanine Jack E. Baldwin, Mark R. Spyvee, Roger C. Whitehead Tetrahedron Letters Stizolobic AcidBioorganic ChemistryBiochemistryNatural SciencesNatural Product Synthesis	1994	25
Taxane diterpenes 5: Synthesis of the A- and C-rings: An unusual rearrangement of an N-hydroxyimino lactone P. Magnus, Nicholas J. Westwood, Mark R. Spyvee, Tetrahedron N-hydroxyimino LactoneBioorganic ChemistryBiochemistryUnusual RearrangementNatural Sciences	1999	24
A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid A and an approach to acromelic acid B Jack E. Baldwin, Andrew M. Fryer, Gareth J. Pritchard, Tetrahedron Combinatorial ChemistryEngineeringBiochemistryNatural SciencesBiomimetic Approach	1998	21
Evaluation of a candidate anti-arthritic drug using the mouse collagen antibody induced arthritis model and clinically relevant biomarkers. Andrew T. Bender, Mark R. Spyvee, Takashi Satoh, PubMed Candidate Rheumatoid ArthritisDisease ReadoutsImmunologyRigorous ScenarioPsoriatic Arthritis	2013	18
Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids Mark R. Spyvee, Huiming Zhang, Lynn D. Hawkins, Bioorganic & Medicinal Chemistry Letters InflammationToll-like ReceptorsPreliminary Sar InvestigationAnti-inflammatoryNovel Synthetic Phospholipids	2005	18

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