Concepedia

Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo

Marc S. Lamphier, Wanjun Zheng, Eicke Latz, Mark R. Spyvee, Hans Hansen, Jeffrey Rose, Melinda Genest, Hua Yang, Christina J. Shaffer, Yan Zhao,

Molecular Pharmacology · 2013 · 141 citations · 28 references

DOI

Concepts

References

28

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi et al. · Nature Immunology · 2002 · 2.5K citations

, , +16

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum et al. · Nature · 2002 · 1.9K citations

, , +14

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

Eicke Latz, Annett Schoenemeyer, Alberto Visintin et al. · Nature Immunology · 2004 · 1.3K citations

, , +6

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

Sean R. Christensen, Jonathan Shupe, Kevin M. Nickerson et al. · Immunity · 2006 · 1.1K citations · Full text

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Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

Terry K. Means, Eicke Latz, Fumitaka Hayashi et al. · Journal of Clinical Investigation · 2005 · 828 citations · Full text

, , +17