The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai, Yosuke Togashi, Takahiro Kamada, +28

Nature Immunology

Cancer ImmunosurveillanceAutoimmune DiseaseT-regulatory CellPd-1 Expression BalanceClinical Efficacy +10

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai, Shohei Koyama, Kota Itahashi, +43

Cancer Cell

Cancer ImmunosurveillancePd-1 ExpressionMedicineT-regulatory CellImmunology +9

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Hiroyuki Mori, Reiko Hanada, Toshikatsu Hanada, +7

Nature Medicine

ObesityMetabolic SyndromeEnergy HomeostasisLeptin SensitivityGastrointestinal Peptide Hormone +11

Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-expressing Tumor Cells

Kazuki N. Sugahara, Toshiyuki Murai, Hitomi Nishinakamura, +3

Journal of Biological Chemistry

Engagement of CD44 Promotes Rac Activation and CD44 Cleavage during Tumor Cell Migration

Toshiyuki Murai, Yoshihiro Miyazaki, Hitomi Nishinakamura, +5

Journal of Biological Chemistry

Induction of Hyper Th1 Cell-Type Immune Responses by Dendritic Cells Lacking the Suppressor of Cytokine Signaling-1 Gene

Toshikatsu Hanada, Kentaro Tanaka, Yumiko Matsumura, +7

The Journal of Immunology

The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization

Kanta Miyoshi, Toru Wakioka, Hitomi Nishinakamura, +7

Oncogene

Signal TransductionCell InteractionGene ExpressionSprouty-related ProteinCytoskeleton +7

HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability

Masahito Kawazu, Toshihide Ueno, Koichi Saeki, +33

Gastroenterology

HistocompatibilityHlaImmune EvasionMedicineGenetics +10

An RNA-binding protein  CP-1 is involved in the STAT3-mediated suppression of NF- B transcriptional activity

Hitomi Nishinakamura, Yasumasa Minoda, Koichi Saeki, +5

International Immunology

HMGB1-Mediated Early Loss of Transplanted Islets Is Prevented by Anti–IL-6R Antibody in Mice

Takeshi Itoh, Tomoyuki Nitta, Hitomi Nishinakamura, +5

Pancreas