Kota Itahashi

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai, Yosuke Togashi, Takahiro Kamada et al. · Nature Immunology · 2020 · 785 citations

Cancer Immunosurveillance, Autoimmune Disease, T-regulatory Cell +12

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai, Shohei Koyama, Kota Itahashi et al. · Cancer Cell · 2022 · 752 citations

Cancer Immunosurveillance, Pd-1 Expression, Medicine +11

Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape

Yoshiko Takeuchi, Tokiyoshi Tanegashima, Eiichi Sato et al. · Science Immunology · 2021 · 124 citations

BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors

Kota Itahashi, Takuma Irie, Junichiro Yuda et al. · Science Immunology · 2022 · 94 citations

TAS-116 (Pimitespib), an Oral HSP90 Inhibitor, in Combination with Nivolumab in Patients with Colorectal Cancer and Other Solid Tumors: An Open-Label, Dose-Finding, and Expansion Phase Ib Trial (EPOC1704)

Akihito Kawazoe, Kota Itahashi, Noboru Yamamoto et al. · Clinical Cancer Research · 2021 · 64 citations · Full text