Daniel Rehling

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Nicholas C.K. Valerie, Anna Hagenkort, Brent D. G. Page et al. · Cancer Research · 2016 · 127 citations

Medicine, Oncology, Pharmacology +13

Development of a chemical probe against NUDT15

Si Min Zhang, Matthieu Desroses, Anna Hagenkort et al. · Nature Chemical Biology · 2020 · 26 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +5

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

Si Min Zhang, Daniel Rehling, Ann‐Sofie Jemth et al. · Cell chemical biology · 2021 · 24 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir

Rina Nishii, Takanori Mizuno, Daniel Rehling et al. · Nature Communications · 2021 · 24 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity

Daniel Rehling, Si Min Zhang, Ann‐Sofie Jemth et al. · Journal of Biological Chemistry · 2021 · 16 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11