Brian E. Libby

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current <i>I</i>_Ks by (<i>R</i>)-2-(2,4- Trifluoromethyl)-<i>N</i>-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-3-yl]acetamide

Harold G. Selnick, Nigel J. Liverton, John J. Baldwin et al. · Journal of Medicinal Chemistry · 1997 · 95 citations · Full text

Medicine, Cardiology, Pharmacology +10

Orally Efficacious NR2B-Selective NMDA Receptor Antagonists

Christopher F. Claiborne, John A. McCauley, Brian E. Libby et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 55 citations · Full text

Medicine, Neurobiology, Pharmacology +11

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Antagonist

Nigel J. Liverton, Rodney A. Bednar, Bohumil Bednár̂ et al. · Journal of Medicinal Chemistry · 2007 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists

Kevin T. Nguyen, Christopher F. Claiborne, John A. McCauley et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10