A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis, Hiroko Koike-Yusa, Étienne De Braekeleer, +24

Cell Reports

Gene Deletion DataGeneticsAcute Myeloid LeukemiaTherapeutic TargetsGenetic Engineering +7

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

Felicity Allen, Luca Crepaldi, Clara Alsinet, +14

Nature Biotechnology

Genome InstabilityDna DamageNatural SciencesGeneticsMolecular Biology +8

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Gabriel Balmus, Domenic Pilger, Julia Coates, +20

Nature Communications

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, +24

Nature Genetics

Hematological MalignancyChromatinSystems BiologyNoncatalytic Inverse RegulationGata Programs +7

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

Wei Lin, Emmanouil Metzakopian, Yannis Emmanuel Mavromatakis, +8

Developmental Biology

Developmental BiologyMolecular NeuroscienceFoxa2 FunctionNeuroanatomyFeedforward Loop +6

Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses

Hugo J. R. Fernandes, Nikolaos Patikas, Stefanie Foskolou, +5

Cell Reports

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Farah H. Siddiqi, Fiona M. Menzies, Ana López, +17

Nature Communications

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Araks Martirosyan, Rizwan Ansari, Francisco Pestana, +14

Molecular Neurodegeneration

Foxa1 and Foxa2 Are Required for the Maintenance of Dopaminergic Properties in Ventral Midbrain Neurons at Late Embryonic Stages

Simon Stott, Emmanouil Metzakopian, Wei Lin, +3

Journal of Neuroscience

Dopaminergic PhenotypeBrain DevelopmentGeneticsMda NeuronsFoxa2 Are Required +17

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Konstantinos Tzelepis, Étienne De Braekeleer, Demetrios Aspris, +32

Nature Communications