Emmanouil Metzakopian

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis, Hiroko Koike-Yusa, Étienne De Braekeleer et al. · Cell Reports · 2016 · 784 citations · Full text

Gene Deletion Data, Genetics, Acute Myeloid Leukemia +9

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

Felicity Allen, Luca Crepaldi, Clara Alsinet et al. · Nature Biotechnology · 2018 · 511 citations · Full text

Genome Instability, Dna Damage, Natural Sciences +10

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Gabriel Balmus, Domenic Pilger, Julia Coates et al. · Nature Communications · 2019 · 178 citations · Full text

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan et al. · Nature Genetics · 2018 · 156 citations · Full text

Hematological Malignancy, Chromatin, Systems Biology +9

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

Wei Lin, Emmanouil Metzakopian, Yannis Emmanuel Mavromatakis et al. · Developmental Biology · 2009 · 155 citations

Developmental Biology, Molecular Neuroscience, Foxa2 Function +8