Jan Wehkamp

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

Wolfgang Hueber, Bruce E. Sands, Steve Lewitzky et al. · Gut · 2012 · 1.5K citations · Full text

Life Sciences, Immunology, Pharmacotherapy +15

Reduced Paneth cell α-defensins in ileal Crohn's disease

Jan Wehkamp, Nita H. Salzman, Edith Porter et al. · Proceedings of the National Academy of Sciences · 2005 · 965 citations · Full text

Life Sciences, Immunology, Pathobiology +17

NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression

Jan Wehkamp, Jürgen Harder, Michael Weichenthal et al. · Gut · 2004 · 796 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A Chromosome 8 Gene-Cluster Polymorphism with Low Human Beta-Defensin 2 Gene Copy Number Predisposes to Crohn Disease of the Colon

Klaus Fellermann, Daniel E. Stange, Elke Schaeffeler et al. · The American Journal of Human Genetics · 2006 · 565 citations · Full text

Medicine, Genetics, Molecular Genetics +17

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by<i>Escherichia coli</i>Nissle 1917: a Novel Effect of a Probiotic Bacterium

Jan Wehkamp, Jürgen Harder, Kai Wehkamp et al. · Infection and Immunity · 2004 · 468 citations · Full text

Life Sciences, Microbiology, Molecular Biology +17