IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Qian Wang, Dehai Li, Guangchao Cao, +32

Nature

ObesityEnergy HomeostasisMedicinePhysiologyMetabolic Regulation +4

γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury

Guodong Sun, Shuxian Yang, Guangchao Cao, +11

The Journal of Experimental Medicine

New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation

Xin Wang, Shaozhen Feng, Jinjin Fan, +3

Biochemical Pharmacology

UrologyFibrosisRenal FunctionKidney ResearchRenal Pathology +11

Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

Zhou Liang, Ziwen Tang, Changjian Zhu, +36

Immunity

InflammationCytokineAutoimmune DiseasePd-1 ExpressionMucosal Immunology +11

Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice

Guangchao Cao, Qian Wang, Wanjun Huang, +19

Cell Discovery

NutritionNutraceutical IngredientImmunologyExperimental NutritionCaffeine Contamination +17

Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis

Junjie Yan, Yingying Zeng, Zerong Guan, +21

Cell Reports

Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity

Jing Zhu, Ruitian Cai, Yuxiang Tan, +6

Journal of Functional Foods

99mTc-labeled SWL specific peptide for targeting EphA2 receptor

Yu Liu, Xiaoli Lan, Tao Wu, +5

Nuclear Medicine and Biology

Signal TransductionEpha2 ReceptorMedicineReceptor (Biochemistry)Peptide Therapeutic +4

A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42‐mediated GSK‐3β/β‐catenin Signaling

Xinrong Hu, Lu Gan, Ziwen Tang, +24

Advanced Science

Chemoprevention StrategyRenal PathologyImmunologyRenal InflammationCdc42‐mediated Gsk‐3β/β‐catenin +21

IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Qihui Liu, Quanli Yang, Zengfeng Wu, +19

Cell Death and Disease