New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai et al. · Proceedings of the National Academy of Sciences · 2001 · 2.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Misako Sato, Yasuteru Muragaki, Shizuya Saika et al. · Journal of Clinical Investigation · 2003 · 744 citations · Full text

Life Sciences, Cell Biology, Pathobiology +17

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Misako Sato, Yasuteru Muragaki, Shizuya Saika et al. · Journal of Clinical Investigation · 2003 · 677 citations

Life Sciences, Cell Biology, Pathobiology +17