Samantha N. Spath

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2<i>H</i>)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Roger B. Ruggeri, Leonard Buckbinder, Scott W. Bagley et al. · Journal of Medicinal Chemistry · 2015 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Mechanistic Characterization of a 2-Thioxanthine Myeloperoxidase Inhibitor and Selectivity Assessment Utilizing Click Chemistry–Activity-Based Protein Profiling

Jessica Ward, Samantha N. Spath, Brandon Pabst et al. · Biochemistry · 2013 · 37 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS⁴)

Kieran F. Geoghegan, Alison H. Varghese, Xidong Feng et al. · Biochemistry · 2012 · 21 citations

Life Sciences, Biochemistry, Molecular Biology +17

Prevalence and diagnosis of hemotrophic mycoplasma infection in research sheep and its effects on hematology variables and erythrocyte membrane fragility.

Joseph A. Hampel, Samantha N. Spath, Ailam Lim et al. · PubMed · 2014 · 17 citations · Full text

Veterinary Medicine, Hematology, Veterinary Microbiology +14