Ed Cleator

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

Neil A. Strotman, Carl A. Baxter, Karel M. J. Brands et al. · Journal of the American Chemical Society · 2011 · 122 citations

Ru Catalyst, Sleep Disorders, Engineering +14

The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder

Carl A. Baxter, Ed Cleator, Karel M. J. Brands et al. · Organic Process Research & Development · 2011 · 100 citations

Sleep Disorders, Pharmacotherapy, Chemistry +19

Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub‐Nanomolar SERCA Inhibition

Stephen P. Andrews, Matthew Ball, Frank Wierschem et al. · Chemistry - A European Journal · 2007 · 90 citations

Five Thapsigargins, Guaianolide Natural Products, Medicinal Chemistry +11

Intramolecular Cyclopropanation of Unsaturated Terminal Epoxides and Chlorohydrins

David M. Hodgson, Ying Kit Chung, Irene Nuzzo et al. · Journal of the American Chemical Society · 2007 · 86 citations

Chemical Engineering, Engineering, Heterocyclic +11

Total synthesis of (−)-nakadomarin A

Andrew F. Kyle, Pavol Jakubec, D.M. Cockfield et al. · Chemical Communications · 2011 · 84 citations

Bioorganic Chemistry, Engineering, Michael Addition +16