Karel M. J. Brands - Concepedia

Author

Karel M. J. Brands

Merck & Co., Inc., Rahway, NJ, USA (United States)

Also Known As

Brands, K.M.J., K BRANDS, K. Brands, K. M. J. BRANDS, K. M. J. Brands, K. M. Jos Brands, K.M. Jos Brands, K.M.J. Brands, Karel Brands, Karel M. Brands

Publications

1.5K

Citations

H-Index

Concepts

All Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)MSD (UK) Limited (United Kingdom)University of Amsterdam

About

Karel M. J. Brands is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in organic chemistry, chemistry, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Biochemistry	14	14	627
2	Natural Sciences	12	12	779
3	Engineering	10	10	445
4	Medicine	9	9	484
5	Biomolecular Engineering	6	6	280

Karel M. J. Brands

Publications

1.3K

Citations

H-Index

Page 1

	Year	Citations
Efficient Synthesis of NK<sub>1</sub> Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation Karel M. J. Brands, Joseph F. Payack, Jonathan D. Rosen, Journal of the American Chemical Society Medicinal ChemistryBiochemistryFunctional SelectivityLewis AcidReceptor Antagonist Aprepitant	2003	156
Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305) Neil A. Strotman, Carl A. Baxter, Karel M. J. Brands, Journal of the American Chemical Society Ru CatalystSleep DisordersEngineeringBiochemistryNatural Sciences	2011	122
Regioselective Synthesis of 1,3,5-Substituted Pyrazoles from Acetylenic Ketones and Hydrazines Brian Bishop, Karel M. J. Brands, Andrew Gibb, Synthesis EngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistrySingle Pyrazole Isomers	2003	103
The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder Carl A. Baxter, Ed Cleator, Karel M. J. Brands, Organic Process Research & Development Sleep DisordersPharmacotherapyChemistryHeterocycle ChemistryPharmaceutical Chemistry	2011	100
Total Synthesis of (-)-Altemicidin: A Novel Exploitation of the Potier-Polonovski Rearrangement Andrew S. Kende, Kun Liu, Karel M. J. Brands Journal of the American Chemical Society Bioorganic ChemistryEngineeringAltmetric Attention ScoreOrganic ChemistryChemistry	1995	69
Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction Matthew M. Zhao, James M. McNamara, Guo-Jie Ho, The Journal of Organic Chemistry Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine	2002	65
Synthesis of the homochiral “tricyclic heart” of manzamine A Karel M. J. Brands, Arthur A. P. Meekel, Upendra K. Pandit Tetrahedron HeterocyclicOrganic ChemistryHeterocycle ChemistryPharmacologySynthetic Chemistry	1991	63
Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition Jeremy P. Scott, Steven F. Oliver, Karel M. J. Brands, The Journal of Organic Chemistry	2006	53
Synthesis of the “tricyclic heart” of manzamines Karel M. J. Brands, Upendra K. Pandit Tetrahedron Letters HeterocyclicBiochemistryOrganic ChemistryHeterocycle ChemistryPharmacology	1989	39
Development of a Phase Transfer Catalyzed Asymmetric Synthesis for an Estrogen Receptor Beta Selective Agonist Jeremy P. Scott, Michael S. Ashwood, Karel M. J. Brands, Organic Process Research & Development Organic ChemistryPractical Asymmetric SynthesisChemistryAsymmetric Michael AdditionMedicinal Chemistry	2007	38

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