Karel M. J. Brands

Efficient Synthesis of NK₁ Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation

Karel M. J. Brands, Joseph F. Payack, Jonathan D. Rosen et al. · Journal of the American Chemical Society · 2003 · 156 citations

Medicinal Chemistry, Biochemistry, Functional Selectivity +14

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

Neil A. Strotman, Carl A. Baxter, Karel M. J. Brands et al. · Journal of the American Chemical Society · 2011 · 122 citations

Ru Catalyst, Sleep Disorders, Engineering +14

Regioselective Synthesis of 1,3,5-Substituted Pyrazoles from Acetylenic Ketones and Hydrazines

Brian Bishop, Karel M. J. Brands, Andrew Gibb et al. · Synthesis · 2003 · 103 citations

Engineering, Natural Sciences, Diversity-oriented Synthesis +10

The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder

Carl A. Baxter, Ed Cleator, Karel M. J. Brands et al. · Organic Process Research & Development · 2011 · 100 citations

Sleep Disorders, Pharmacotherapy, Chemistry +19

Total Synthesis of (-)-Altemicidin: A Novel Exploitation of the Potier-Polonovski Rearrangement

Andrew S. Kende, Kun Liu, Karel M. J. Brands · Journal of the American Chemical Society · 1995 · 69 citations

Bioorganic Chemistry, Engineering, Altmetric Attention Score +17