Yoannis Imbert-Fernandez

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

Brian F. Clem, Julie O’Neal, Gilles Tapolsky et al. · Molecular Cancer Therapeutics · 2013 · 272 citations · Full text

Tumor Biology, Biochemistry, Medicine +13

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

Brian F. Clem, Yoannis Imbert-Fernandez, Selahattin Can Özcan et al. · Cell Death and Disease · 2014 · 201 citations · Full text

Apoptosis, Cell Death, Cell Cycle +22

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

Julie O’Neal, Amy Clem, Lindsey Reynolds et al. · Breast Cancer Research and Treatment · 2016 · 105 citations

Her2+ Breast Cancer, Breast Oncology, Glucose Metabolism +11

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

Alden C. Klarer, Julie O’Neal, Yoannis Imbert-Fernandez et al. · Cancer & Metabolism · 2014 · 100 citations · Full text

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

Jason Chesney, Jennifer A. Clark, Alden C. Klarer et al. · Oncotarget · 2014 · 93 citations · Full text