Concepedia

Alden C. Klarer

AC

8

Publications

869

Citations

8

H-Index

2011

Active since

Affiliations

University of Louisville(Current)

James Graham Brown Foundation

Alden C. Klarer is an author at University of Louisville specializing in medicine, biochemistry, and tumor biology.

Top concepts

Publications per year

2011–2014

8

Publications

8

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

Brian F. Clem, Julie O’Neal, Gilles Tapolsky et al. · Molecular Cancer Therapeutics · 2013 · 272 citations · Full text

, , +13

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

Brian F. Clem, Yoannis Imbert-Fernandez, Selahattin Can Özcan et al. · Cell Death and Disease · 2014 · 201 citations · Full text

, , +22

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

Alden C. Klarer, Julie O’Neal, Yoannis Imbert-Fernandez et al. · Cancer & Metabolism · 2014 · 100 citations · Full text

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

Jason Chesney, Jennifer A. Clark, Alden C. Klarer et al. · Oncotarget · 2014 · 93 citations · Full text

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

Sucheta Telang, Brian F. Clem, Alden C. Klarer et al. · Journal of Translational Medicine · 2012 · 92 citations · Full text

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