Concepedia

Mari Manuia

MM

8

Publications

1.5K

Citations

8

H-Index

2008

Active since

Affiliations

Genomics Institute of the Novartis Research Foundation(Current)

D. E. Shaw Research

Mari Manuia is an author at Genomics Institute of the Novartis Research Foundation specializing in medicine, drug discovery, and pharmacology.

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Publications per year

2008–2021

8

Publications

8

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 851 citations · Full text

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Superoxide dismutase 1 (SOD1) is essential for H <sub>2</sub> O <sub>2</sub> -mediated oxidation and inactivation of phosphatases in growth factor signaling

Jose C. Juarez, Mari Manuia, Mark E. Burnett et al. · Proceedings of the National Academy of Sciences · 2008 · 255 citations · Full text

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EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

Yong Jia, Jose Juarez, Jie Li et al. · Cancer Research · 2016 · 120 citations · Full text

Discovery of (<i>R</i>,<i>E</i>)-<i>N</i>-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

G. Lelais, Robert Epple, Thomas H. Marsilje et al. · Journal of Medicinal Chemistry · 2016 · 94 citations · Full text

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Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth

Fernando Doñate, Graham C. Parry, Yuval Shaked et al. · Clinical Cancer Research · 2008 · 91 citations · Full text

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