Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

María Teresa Herrera-Abreu, Marta Palafox, Uzma Asghar, +17

Cancer Research

Pi3k InhibitorsBreast OncologyEstrogen ReceptorCancer BiologyTumor Biology +17

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

Lesley‐Ann Martin, Ricardo Ribas, Nikiana Simigdala, +25

Nature Communications

Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance

Iván Plaza-Menacho, Andrea Morandi, David Robertson, +5

Oncogene

Breast OncologyHormonal ReceptorReceptor Tyrosine KinaseBreast Cancer CellsEndocrine Resistance +6

Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer.

Stephen Johnston, Julia E. Head, Sunil Pancholi, +4

PubMed

Breast OncologyHormone ResistancePharmacotherapySignal Transduction InhibitorsEndocrine Oncology +17

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

Nikiana Simigdala, Qiong Gao, Sunil Pancholi, +8

Breast Cancer Research

PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

Élodie Montaudon, Joanna Nikitorowicz-Buniak, Laura Sourd, +35

Nature Communications

GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors

Andrea Morandi, Lesley‐Ann Martin, Qiong Gao, +7

Cancer Research

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer

Xiaoling Puyang, Craig Furman, Guo Zhu Zheng, +50

Cancer Discovery

A Simple Organ Culture Model for Assessing the Effects of Growth Factors on Corneal Re-epithelialization

David Foreman, Sunil Pancholi, John Jarvis-Evans, +2

Experimental Eye Research

Developmental BiologyOphthalmologyCorneal DystrophyGrowth FactorsWound Healing +4

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer

Kimberly J. Cocce, Jeff S. Jasper, Taylor K. Desautels, +29

Cell Reports

Breast OncologyCancer BiologyMammary Gland DevelopmentTumor BiologyTranscriptional Regulation +14