James Pan

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar et al. · Nature Medicine · 2016 · 304 citations

Rnf43-mutant Pancreatic Tumors, Signaling Pathway, Genome-wide Crispr Screens +12

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

Parvez Vora, Chitra Venugopal, Sabra K. Salim et al. · Cell stem cell · 2020 · 179 citations · Full text

Neuro-oncology, Rational Development, Immunology +6

A new nomenclature for IL-1-family genes

John E. Sims, Yang Pan, Dirk E. Smith et al. · Trends in Immunology · 2001 · 176 citations

Immunogenetics, Autoimmune Disease, Genetics +6

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

Brenda Cohen, Mamiko Shimizu, Julia Izrailit et al. · Breast Cancer Research and Treatment · 2009 · 159 citations

Cancer Research, Breast Oncology, Signal Transduction +11

Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours

Helen Mackay, Hal W. Hirte, Terrence J. Colgan et al. · European Journal of Cancer · 2010 · 145 citations

Phase Ii Trial, Medicine, Ovarian Tumours +7