Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, +14

Nature Medicine

Rnf43-mutant Pancreatic TumorsSignaling PathwayGenome-wide Crispr ScreensDruggable VulnerabilityCancer Cell Biology +10

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

Parvez Vora, Chitra Venugopal, Sabra K. Salim, +25

Cell stem cell

Neuro-oncologyRational DevelopmentImmunologyImmune Checkpoint InhibitorImmunotherapeutics +4

A new nomenclature for IL-1-family genes

John E. Sims, Yang Pan, Dirk E. Smith, +11

Trends in Immunology

ImmunogeneticsAutoimmune DiseaseGeneticsImmunologyMolecular Genetics +4

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

Brenda Cohen, Mamiko Shimizu, Julia Izrailit, +5

Breast Cancer Research and Treatment

Cancer ResearchBreast OncologySignal TransductionJag1-mediated Notch SignalingSignaling Pathway +9

Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours

Helen Mackay, Hal W. Hirte, Terrence J. Colgan, +10

European Journal of Cancer

Phase Ii TrialMedicineOvarian TumoursGynecologyCancer Treatment +5

Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?

James Pan, Tak W. Mak

Science s STKE

Chemoprevention StrategyUse GlycolysisMetabolic RemodelingTumor BiologyNew Era +19

Protocadherin-1 is essential for cell entry by New World hantaviruses

Rohit K. Jangra, Andrew S. Herbert, Rong Li, +26

Nature

Molecular VirologyNew WorldPathogenesisImmunologyViral Pathogenesis +6

<i>MDR1</i> Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

King Leung Fung, James Pan, Shinobu Ohnuma, +5

Cancer Research

Atpase Activity AssaysMolecular PhysiologySignal TransductionProtein StabilitySomatic Variant +12

The Kil Peptide of Bacteriophage λ Blocks Escherichia coli Cytokinesis via ZipA-Dependent Inhibition of FtsZ Assembly

Daniel P. Haeusser, Marina Hoashi, Anna I. Weaver, +6

PLoS Genetics

Molecular RegulationBacteriophageMolecular BiologyCytoskeletonAnalytical Ultracentrifugation +18

A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties

Zvezdan Pavlovic, Jarrett Adams, Levi L. Blazer, +9

mAbs

EngineeringImmunologyAnti-tumor PropertiesImmunotherapeuticsBiomedical Engineering +20